Toward a molecular understanding of iron acquisition and homeostasis in Pseudomonas aeruginosa
February 17, Tue 2009
1:00 pm, MRB 100 Conference Room
Dr. Mario Rivera
University of Kansas
Efforts in our laboratories are aimed at understanding at a fundamental level the structure, function, dynamics and interactions of proteins involved in heme-iron metabolism and iron homeostasis in the opportunistic P. aeruginosa. The lecture will summarize recent successes and challenges in the quest to obtain the structural characterization of proteins involved in (1) the piracy of heme from the host hemoglobin (2) the degradation of the heme in the cytosol to release iron and (3) the mobilization of iron from bacterioferritin, a protein that stores iron and enables the organism’s survival while other mechanisms are activated to procure the nutrient from extracellular sources.