College of Liberal Arts & Sciences

Sequence-homology based approach in modeling of protein-protein interactions

Feb 5, Tue 2007
11:00 am, MRB 200 Conference Room

Petras Kundrotas

Center for Bioinformatics, University of Kansas

Results of the research covered in this talk are related to various aspects of sequence-homology based modeling of 3D structures of protein-protein complexes. First, the quality of homology models will be compared for two different sequence alignment protocols, the PSI-BLAST search and alignment of modified sequence profiles. The second part is related to introduction of additional information into query (target) sequence profile and presents a new method for predicting interfacial residues based on the sequence information alone. Finally, the way of model verification based on electrostatic properties of protein complexes will be presented.


One of 34 U.S. public institutions in the prestigious Association of American Universities
44 nationally ranked graduate programs.
—U.S. News & World Report
Top 50 nationwide for size of library collection.
—ALA
23rd nationwide for service to veterans —"Best for Vets," Military Times
KU Today