Protein Comparison: From New Methods to Unexpected Discoveries
Apr 22, Tue 2008
11:00 am, MRB 200 Conference Room
Dr. Nick Grishin
Department of Biochemistry, University of Texas Southwestern Medical Center,
Several new methods for remote homology inference between proteins, multiple alignment and structure similarity search will be discussed; and their applications to uncover unexpected and biologically meaningful connections between proteins will be demonstrated. In particular, a few examples of evolutionarily related proteins with very different spatial structure will be shown. The most extreme case is an all-beta barrel protein family with a few members folded as an alpha-helical hairpin.