October 22, Tue 2013
1:00 pm, MRB 200 Conference Room
Dr. Patrick Barth
Departments of Pharmacology, Biochemistry & Molecular Biology, Baylor College of Medicine
High-Resolution Modeling and Design of Membrane Proteins
Reliable structure prediction methods for membrane proteins are important because the experimental determination of high-resolution membrane protein structures remains very difficult, especially for eukaryotic proteins. The laboratory develops the method RosettaMembrane for the high-resolution modeling and design of membrane proteins and recent developments and achievements of the method will be presented. How membrane protein structures can be accurately modeled from distant homologs will be discussed. Applications combining modeling and design techniques to reprogram the conformational regulation of membrane receptor signaling and the associations between membrane proteins will also be described.