College of Liberal Arts & Sciences

From genome to gene expression: Understanding protein interactions and host-pathogen interactions

Feb 15, Thu 2007
12:00pm - 1:00pm, 2001 Mallott

Huiying Li

UCLA-DOE Institute for Genomics and Proteomics

 

Genome-scale reconstruction of protein-protein interaction networks proves an efficient strategy for gathering functional information about proteins which cannot be characterized using homology-based methods alone. By examining linkages between characterized and unknown (or hypothetical) entities, individual proteins or logical protein groups can be assigned putative function based on the ‘guilt-by-association’ principle, within the context of the network. Such large-scale interactome models also provide information about local and global relationships between gene products, and can be used to elucidate novel pathways, study cellular behavior, or predict outcomes based on possible propagation routes of effects exerted by small molecules.

1.      Huiying Li, Matteo Pellegrini, David Eisenberg.  Detection of parallel functional modules by comparative analysis of genome sequences.  Nature Biotechnology, 23(2):253-260 (2005).

2.      Philip T. Liu, Steffen Stenger, Huiying Li, et al.  Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.  Science, 311:1770-1773 (2006).


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