Bioinformatics of Polyanion Binding Proteins
Sep 18, Tue 2007
2:00 pm, MRB Conference Room
Dr. Jianwen Fang
ITTC and Bioinformatics Core Facility, University of Kansas
The interactions between polyanions (PAs) and polyanion binding proteins (PABPs) have been found to play significant roles in many essential biological processes including intracellular organization, transport and protein folding. Furthermore, many neurodegenerative disease related proteins are PABPs. In this talk I will present our recent bioinformatics studies on PA/PABP interactions. We have provided evidences for the existence of a network-like system for PA/PABP interactions within cells and their potential roles as critical hubs in intracellular behavior. In addition, we have developed machine learning models to predict PABPs based on their sequence information and physicochemical properties. A web-based database (http://pabp.bcf.ku.edu/DB_PABP) has been developed and used in datamining studies.